Bigelow Pharmacy (on Sixth Ave): Founded in 1838, it is the most amazing source for hard to find toiletries from around the world.
Canine Styles: The store is a very trendy dog experience. Here you will find the top quality dog accessories, ranging from carriers to coats and sweaters.
Mxyplyzyk: Great attitude in the selection of home and giftwares.
Fire Store: You can buy authentic fireman's garb and other clever spinoffs at this New York City Fire Department shop.
Jonathan Adler: Designs needlepoint pillows to backgammon boards as well as kitsch ceramics.
Jessie James: Small clothing outpost with downtown attitude.
Alphabets: A rarefied slightly irreverent gift store, also has an outpost in the East Village.